Article
Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas.
British journal of cancer - 16 Jun 2003
Yoshimura S, Yamada T, Ohwada S, Koyama T, Hamada K, Tago K, Sakamoto I, Takeyoshi I, Ikeya T, Makita F, Iino Y, Morishita Y
Abstract excerpt
Human cancers frequently show a loss of heterozygosity on chromosome 7q31, which indicates the existence of broad-range tumour-suppressor gene(s) at this locus. Truncating mutations in the ST7 gene at this locus are seen frequently in primary colon cancer and breast cancer cell lines. Therefore,...
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