Article
The importance of genetic recombination for fidelity of chromosome pairing in meiosis.
Developmental cell - 1 Dec 2003
Tsubouchi Hideo, Roeder G Shirleen
Abstract excerpt
In budding yeast, absence of the Hop2 protein leads to extensive synaptonemal complex (SC) formation between nonhomologous chromosomes, suggesting a crucial role for Hop2 in the proper alignment of homologous chromosomes during meiotic prophase. Genetic analysis indicates that Hop2 acts in the same pathway as the Rad51 and Dmc1 proteins, two homologs of E. coli RecA. Thus, the hop2 mutant phenotype demonstrates...
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