Article
Congenic mice reveal sex-specific genetic regulation of femoral structure and strength.
Calcified tissue international - 1 Sept 2003
Turner C H, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein M L, Rosen C J, Donahue L R, Shultz K L, Beamer W G
Abstract excerpt
Genetic linkage studies in C3H/HeJ (C3H) and C57BL/6J (B6) mice identified several chromosomal locations or quantitative trait loci (QTL) linked to femoral volumetric bone mineral density (vBMD). From QTL identified on chromosomes (chr) 1, 4, 6, 13, and 18, five congenic mouse strains were developed. In each of these mice, genomic DNA from the QTL region of the donor C3H strain was transferred into the recipient...
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