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Article

Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells.

Molecular and cellular neurosciences - 1 Nov 2003

Cheng Qi, Sasaki Yukio, Shoji Masayuki, Sugiyama Yoshinobu, Tanaka Hideaki, Nakayama Takashi, Mizuki Nobuhisa, Nakamura Fumio, Takei Kohtaro, Goshima Yoshio

Abstract excerpt

Ephrin-As are repulsive axonal guidance cues that regulate retinotectal projection. EphA tyrosine kinases, which are the receptors of ephrin-As, activate signaling cascades leading to cytosckeleton reorganization. Here, we address the role of cyclin-dependent kinase (Cdk) 5 in Eph receptor signaling induced by ephrin-A5. Ephrin-A5 induced a cell morphological response in PC-3M cells that endogenously express Cdk5...

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Identifiers

PMID: 14664814
DOI: 10.1016/s1044-7431(03)00220-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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