Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1.

Molecular and cellular neurosciences - 1 Sept 2015

Posada-Duque Rafael Andrés, Palacio-Castañeda Valentina, Cardona-Gómez Gloria Patricia

Abstract excerpt

Astrocytes perform metabolic and structural support functions in the brain and contribute to the integrity of the blood-brain barrier. Astrocytes influence neuronal survival and prevent gliotoxicity by capturing glutamate (Glu), reactive oxygen species, and nutrients. During these processes, astrocytic morphological changes are supported by actin cytoskeleton remodeling and require the involvement of Rho GTPases,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 5

Share to Excitatory Amino Acid Agonists

Share to Neuroprotection

Share to Purines

Share to rac1 GTP-Binding Protein

Share to rhoA GTP-Binding Protein

Source

Identifiers

PMID: 26160434
DOI: 10.1016/j.mcn.2015.07.001

Genes

CDK5
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1.PMID 26160434Read ↗

Astroglial Dysfunction in Models of CDKL5 Deficiency DisorderSemantic proximity Read ↗

Neuroprotective function of astrocyte p75 <sup>NTR</sup> in Alzheimer’s Disease through regulation of cholesterol metabolismSemantic proximity Read ↗

Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer’s DiseaseSemantic proximity Read ↗

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytesSemantic proximity Read ↗

Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes.Semantic proximity Read ↗

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth.Semantic proximity Read ↗

Cdk5: mediator of neuronal death and survivalSemantic proximity Read ↗

Establishment and characterization of a new conditionally immortalized human astrocyte cell lineSemantic proximity Read ↗

Short and long TNF-alpha exposure recapitulates canonical astrogliosis events in human induced pluripotent stem cells-derived astrocytesSemantic proximity Read ↗

Rethinking Intellectual Disability from Neuro- to Astro-Pathology.Semantic proximity Read ↗

Chronic activation of astrocytic G <sub>q</sub> GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseasesSemantic proximity Read ↗

A role for astroglia in prion diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.