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Article

Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia.

Molecular and cellular neurosciences - 1 Jul 2014

Ito Yuki, Asada Akiko, Kobayashi Hiroyuki, Takano Tetsuya, Sharma Govinda, Saito Taro, Ohta Yasutaka, Amano Mutsuki, Kaibuchi Kozo, Hisanaga Shin-Ichi

Abstract excerpt

Cdk5 is a member of the cyclin-dependent kinase (Cdk) family that plays a role in various neuronal activities including brain development, synaptic regulation, and neurodegeneration. Cdk5 requires the neuronal specific activators, p35 and p39 for subcellular compartmentalization. However, it is not known how active Cdk5 is recruited to F-actin cytoskeleton, which is a Cdk5 target. Here we found p35 and p39...

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PMID: 24877974
DOI: 10.1016/j.mcn.2014.05.006

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