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Article

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

Journal of cell science - 1 Mar 2002

Lawrenson Isobel D, Wimmer-Kleikamp Sabine H, Lock Peter, Schoenwaelder Simone M, Down Michelle, Boyd Andrew W, Alewood Paul F, Lackmann Martin

Abstract excerpt

Eph receptor tyrosine kinases and ephrins regulate morphogenesis in the developing embryo where they effect adhesion and motility of interacting cells. Although scarcely expressed in adult tissues, Eph receptors and ephrins are overexpressed in a range of tumours. In malignant melanoma, increased Eph and ephrin expression levels correlate with metastatic progression. We have examined cellular and biochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11870224
DOI: 10.1242/jcs.115.5.1059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.PMID 11870224Read ↗

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Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.Semantic proximity Read ↗

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Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.Semantic proximity Read ↗

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