Article
Silencing of EphA3 through a cis interaction with ephrinA5.
Nature neuroscience - 1 Mar 2006
Carvalho Ricardo F, Beutler Martin, Marler Katharine J M, Knöll Bernd, Becker-Barroso Elena, Heintzmann R, Ng Tony, Drescher Uwe
Abstract excerpt
EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants of ephrinA5 and fluorescence resonance energy transfer technology to uncover a cis interaction...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.