Article
Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E(2).
Cancer science - 1 Dec 2003
Sato Marimo, Takayama Takuya, Tanaka Hiroaki, Konishi Juichiro, Suzuki Toshihiro, Kaiga Teruo, Tahara Hideaki
Abstract excerpt
Dendritic cell (DC) administration appears to be a very promising approach for the immunotherapy of cancer. The results of clinical studies have suggested that the nature and the magnitude of antitumor immune responses are critically affected by DC functions, including production of T helper type 1 (Th1)-inducing cytokines, activation of T cell subsets and natural killer (NK) cells, and migration from peripheral...
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