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Article

Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.

Scientific reports - 9 Apr 2018

Shinde Prajakta, Fernandes Sophia, Melinkeri Sameer, Kale Vaijayanti, Limaye Lalita

Abstract excerpt

Dendritic cells (DCs) have the potential to elicit long-lasting anti-tumour immune responses. Most of the clinical trials of anti-cancer DC vaccines are based on monocyte-derived DCs (Mo-DCs). However, their outcomes have shown limited promise especially in multiple myeloma (MM) patients. Here, we investigated whether in vitro generated Mo-DCs from MM patients (MM-DCs) possess impaired functionality, thus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29632307
DOI: 10.1038/s41598-018-23943-w
PMCID: PMC5890285

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