Article
Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour.
Oncogene - 18 Mar 2004
Oliveira Carla, de Bruin Joyce, Nabais Sérgio, Ligtenberg Marjolijn, Moutinho Cátia, Nagengast Fokko M, Seruca Raquel, van Krieken Han, Carneiro Fátima
Abstract excerpt
Mutations in CDH1, encoding E-cadherin, are the underlying genetic defect in approximately one-third of the hereditary diffuse gastric cancer (HDGC) families described so far. Tumours arising in these families show abnormal or absence of E-cadherin expression, following the model of tumour suppressor gene inactivation. A single study has been reported showing inactivation of the CDH1 wild-type allele in tumour...
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