Article
E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma.
Oncogene - 22 Mar 2001
Machado J C, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F, Sobrinho-Simöes M
Abstract excerpt
In diffuse gastric carcinoma, despite common E-cadherin gene (CDH1) mutations, tumors show absence of CDH1 loss of heterozigosity (LOH) in most cases. This observation challenges the classical two-hit model of tumor suppressor gene inactivation. In order to investigate whether or not CDH1 promote...
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