Article
Mutations of the human E-cadherin (CDH1) gene.
Human mutation - 1 Jan 1998
Berx G, Becker K F, Höfler H, van Roy F
Abstract excerpt
The cell-cell adhesion molecule E-cadherin is well known to act as a strong invasion suppressor in experimental tumor cell systems. Frequent inactivating mutations have been identified for the E-cadherin gene (CDH1) in diffuse gastric cancers and lobular breast cancers. To date, 69 somatic mutations have been reported comprising, in addition to few missense mutations, mainly splice site mutations and truncation...
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