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Article

Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.

The Journal of biological chemistry - 20 Feb 2004

Reader John S, Metzgar David, Schimmel Paul, de Crécy-Lagard Valérie

Abstract excerpt

Queuosine (Q) is a hypermodified 7-deazaguanosine nucleoside located in the anticodon wobble position of four amino acid-specific tRNAs. In bacteria, Q is produced de novo from GTP via the 7-deazaguanosine precursor preQ1 (7-aminoethyl 7-deazaguanine) by an uncharacterized pathway. PreQ1 is subsequently transferred to its specific tRNA by a tRNA-guanine transglycosylase (TGT) and then further modified in situ to...

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PMID: 14660578
DOI: 10.1074/jbc.M310858200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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