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Article

Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases.

Biochemical and biophysical research communications - 24 Jun 2011

Eric Thomas C, Chen Yi-Chen, Garcia George A

Abstract excerpt

tRNA-guanine transglycosylases (TGTs) are responsible for incorporating 7-deazaguanine-modified bases into certain tRNAs in eubacteria (preQ(1)), eukarya (queuine) and archaea (preQ(0)). In each kingdom, the specific modified base is different. We have found that the eubacterial and eukaryal TGTs have evolved to be quite specific for their cognate heterocyclic base and that Cys145 (Escherichia coli) is important...

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Identifiers

PMID: 21640076
DOI: 10.1016/j.bbrc.2011.05.100
PMCID: PMC3124622

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