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Article

Novel genomic island modifies DNA with 7-deazaguanine derivatives.

Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2016

Thiaville Jennifer J, Kellner Stefanie M, Yuan Yifeng, Hutinet Geoffrey, Thiaville Patrick C, Jumpathong Watthanachai, Mohapatra Susovan, Brochier-Armanet Celine, Letarov Andrey V, Hillebrand Roman, Malik Chanchal K, Rizzo Carmelo J, Dedon Peter C, de Crécy-Lagard Valérie

Abstract excerpt

The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and DNA metabolism genes, led to the hypothesis that 7-deazaguanine derivatives are inserted in DNA. This was established by detecting 2'-deoxy-preQ0 and 2'-deoxy-7-amido-7-deazaguanosine in enzymatic hydrolysates of DNA extracted from the...

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PMID: 26929322
DOI: 10.1073/pnas.1518570113
PMCID: PMC4801273

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