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Article

Progastrin is directed to the regulated secretory pathway by synergistically acting basic and acidic motifs.

The Journal of biological chemistry - 13 Feb 2004

Bundgaard Jens R, Birkedal Henrik, Rehfeld Jens F

Abstract excerpt

Bioactivation of prohormones occurs in the granules of the regulated secretory pathway of endocrine cells, which release hormones in response to external stimulation. How secretory granules are formed and how the cargo is selected is still unclear, but it has been shown for several prohormones and processing enzymes that domains within the prohormone structure can act as "sorting signals" for this pathway. The...

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Identifiers

PMID: 14660571
DOI: 10.1074/jbc.M310547200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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