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Article

Insertion of dibasic residues directs a constitutive protein to the regulated secretory pathway.

Biochemical and biophysical research communications - 11 Jan 2002

Féliciangéli Sylvain, Kitabgi Patrick

Abstract excerpt

The mechanisms for sorting proteins to the regulated secretory pathway (RSP) remains poorly understood. We recently reported that dibasic sequences that are cleaved by pro-protein convertases (PCs) in pro-neurotensin also acted as sorting signal for the precursor. Here we addressed two questions regarding the role of dibasics as sorting signal: (i) Are dibasics sufficient to direct proteins to the RSP? (ii) Do...

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Identifiers

PMID: 11779152
DOI: 10.1006/bbrc.2001.6137

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