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Article

Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.

Gastroenterology - 1 Nov 1998

Bishop L, Dimaline R, Blackmore C, Deavall D, Dockray G J, Varro A

Abstract excerpt

BACKGROUND & AIMS: Amidated gastrins are acid secretagogues and growth factors. Their precursor, progastrin, is a growth factor but not a secretagogue. Cleavage of progastrin at Arg94/95 determines the expression of these two alternative patterns of biological activity. We examined the hypothesis that cleavage at Arg94/95 is regulated by phosphorylation of the adjacent Ser96 residue. METHODS: Hamster insulinoma...

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PMID: 9797370
DOI: 10.1016/s0016-5085(98)70086-1

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CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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