Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.

doi:10.1016/s0016-5085(98)70086-1

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Article

Modulation of the cleavage of the gastrin precursor by prohormone phosphorylation.

Gastroenterology - 1 Nov 1998

Bishop L, Dimaline R, Blackmore C, Deavall D, Dockray G J, Varro A

Abstract excerpt

BACKGROUND & AIMS: Amidated gastrins are acid secretagogues and growth factors. Their precursor, progastrin, is a growth factor but not a secretagogue. Cleavage of progastrin at Arg94/95 determines the expression of these two alternative patterns of biological activity. We examined the hypothesis...

Topics

Amino Acid Sequence
Animals
Calcium
Casein Kinases
Cricetinae
Gastrins
Insulinoma
Mutation
Peptide Fragments
Phosphorylation
Protein Kinases
Protein Precursors
Rats
Transfection
Tumor Cells, Cultured

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