Article
Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5'-flanking region.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Nov 2003
Hamzeiy H, Bombail V, Plant N, Gibson G, Goldfarb P
Abstract excerpt
1. Understanding the genetic basis of interindividual variability in drug disposition and response is a fundamental focus for rational and individualized drug treatment. Cytochrome P4503A4 (CYP3A4) has a central role in human drug metabolism and polymorphic variation has been reported in this gene. 2. This study reports the in vitro functional analysis of inherited mutations in the 5' flanking region of the...
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