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Article

Increased transcriptional activity of the CYP3A4*1B promoter variant.

Environmental and molecular mutagenesis - 1 Jan 2003

Amirimani B, Ning B, Deitz A C, Weber B L, Kadlubar F F, Rebbeck T R

Abstract excerpt

Numerous single nucleotide polymorphisms (SNPs) have been identified in the human genome, yet the functional significance of most is unknown. CYP3A4 is a key enzyme in the metabolism of numerous compounds. An A-->G substitution 290 bp upstream of the CYP3A4 transcription start site (CYP3A4*1B) has been associated with cancer phenotypes, but its phenotypic effects are unclear. To investigate the functional...

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PMID: 14673875
DOI: 10.1002/em.10199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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