Article
Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP.
Mutation research - 20 Mar 2002
Hamzeiy Hossein, Vahdati-Mashhadian Nasser, Edwards Helen J, Goldfarb Peter S
Abstract excerpt
Human CYP3A4 is the major cytochrome P450 isoenzyme in adult human liver and is known to metabolise many xenobiotic and endogenous compounds. There is substantial inter-individual variation in the hepatic levels of CYP3A4. Although, polymorphic mutations have been reported in the 5' regulatory re...
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