Article
Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP.
Mutation research - 20 Mar 2002
Hamzeiy Hossein, Vahdati-Mashhadian Nasser, Edwards Helen J, Goldfarb Peter S
Abstract excerpt
Human CYP3A4 is the major cytochrome P450 isoenzyme in adult human liver and is known to metabolise many xenobiotic and endogenous compounds. There is substantial inter-individual variation in the hepatic levels of CYP3A4. Although, polymorphic mutations have been reported in the 5' regulatory region of the CYP3A4 gene, those that have been investigated so far do not appear to have any effect on gene expression....
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