Identification of a novel polymorphic enhancer of the human CYP3A4 gene.

doi:10.1124/mol.65.2.326

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Article

Identification of a novel polymorphic enhancer of the human CYP3A4 gene.

Molecular pharmacology - 1 Feb 2004

Matsumura Keiko, Saito Tetsuya, Takahashi Yoshiki, Ozeki Takeshi, Kiyotani Kazuma, Fujieda Masaki, Yamazaki Hiroshi, Kunitoh Hideo, Kamataki Tetsuya

Abstract excerpt

CYP3A4, the most abundant form of cytochrome P450 in the human adult liver, shows wide interindividual variation in its activity. This variability is thought to be caused largely by transcriptional and genetic factors, yet the underlying mechanisms are poorly understood. The purpose of this study was to clarify the mechanisms controlling the CYP3A4 gene transcription and to search for genetic polymorphisms in the...

Topics

5' Flanking Region
Base Sequence
Binding Sites
Cell Line, Tumor
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Enhancer Elements, Genetic
Genetic Variation
Humans
Molecular Sequence Data
Polymorphism, Genetic

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Identifiers

PMID: 14742674
DOI: 10.1124/mol.65.2.326

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