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Article

Identification of a novel polymorphic enhancer of the human CYP3A4 gene.

Molecular pharmacology - 1 Feb 2004

Matsumura Keiko, Saito Tetsuya, Takahashi Yoshiki, Ozeki Takeshi, Kiyotani Kazuma, Fujieda Masaki, Yamazaki Hiroshi, Kunitoh Hideo, Kamataki Tetsuya

Abstract excerpt

CYP3A4, the most abundant form of cytochrome P450 in the human adult liver, shows wide interindividual variation in its activity. This variability is thought to be caused largely by transcriptional and genetic factors, yet the underlying mechanisms are poorly understood. The purpose of this study was to clarify the mechanisms controlling the CYP3A4 gene transcription and to search for genetic polymorphisms in the...

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Source

Identifiers

PMID: 14742674
DOI: 10.1124/mol.65.2.326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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