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Article

CYP3A4*1G regulates CYP3A4 intron 10 enhancer and promoter activity in an allelic-dependent manner.

International journal of clinical pharmacology and therapeutics - 1 Aug 2015

Yang Weihong, Zhao Dengzhi, Han Shengna, Tian Zengyuan, Yan Liang, Zhao Guoqiang, Kan Quancheng, Zhang Wei, Zhang Lirong

Abstract excerpt

OBJECTIVE: CYP3A4*1G (G > A) in human CYP3A4 intron 10 is associated with therapeutic effects of CYP3A4-metabolized drugs. The aim of this study was to predict its function in the regulation of CYP3A4 expression. METHODS: Functional analysis of the CYP3A4*1G allele was performed using bioinformatic methods and enhancer or promoter reporter assays in HepG2 cells. RESULTS: Transcription regulatory elements like...

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Source

Identifiers

PMID: 25997547
DOI: 10.5414/CP202272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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