Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An improved growth hormone reporter gene shows a different pattern of transactivation by promoter fragments.

Gene - 24 Dec 2003

Schembri-Wismayer Pierre, Birnie George D

Abstract excerpt

Granulocytic differentiation of myeloid NB4 cells was noted to transactivate the genomic human growth hormone (hGH) reporter construct in the absence of a driving test promoter. Such spurious hGH transactivation also occurred upon co-transfection of plasmids expressing the transactivators c-Myb and C/EBPalpha into undifferentiated NB4 cells. Modifications to the reporter gene and the vector resulted in a reporter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Reporter
Share to Genetic Vectors
Share to HL-60 Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human Growth Hormone

Share to Recombinant Fusion Proteins

Share to Sequence Deletion

Share to Transcriptional Activation

Share to Up-Regulation

Source

Identifiers

PMID: 14659891
DOI: 10.1016/j.gene.2003.09.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An improved growth hormone reporter gene shows a different pattern of transactivation by promoter fragments.PMID 14659891Read ↗

Transcriptional activation of the human growth hormone gene by ras oncogene.Semantic proximity Read ↗

Identification of a Discrete Promoter Region of the Human GnRH Gene That Is Sufficient for Directing Neuron-Specific Expression: A Role for POU Homeodomain Transcription FactorsSemantic proximity Read ↗

Comparative studies of nondeletional HPFH gamma-globin gene promoters.Semantic proximity Read ↗

Protein-DNA interactions during phenotypic differentiation.Semantic proximity Read ↗

Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression.Semantic proximity Read ↗

Identification of a growth hormone gene promoter repressor element and its cognate double- and single-stranded DNA-binding proteins.Semantic proximity Read ↗

Progressive inactivation of the expression of an erythroid transcriptional factor in GM- and G-CSF-dependent myeloid cell lines.Semantic proximity Read ↗

Transcriptional activation potential of normal and tumor-associated myb isoforms does not correlate with their ability to block GCSF-induced terminal differentiation of murine myeloid precursor cells.Semantic proximity Read ↗

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.Semantic proximity Read ↗

DNA damage response of cloned DNA beta-polymerase promoter is blocked in mutant cell lines deficient in protein kinase A.Semantic proximity Read ↗

Transcriptional activation of the human gastrin-releasing peptide receptor gene in gastrointestinal and prostatic epithelial cancer cells.Semantic proximity Read ↗

In vitro activation of distinct molecular and cellular phenotypes after induction of differentiation in a human neuroblastoma cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.