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Article

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1996

Liu C, Adamson E, Mercola D

Abstract excerpt

The early growth response 1 (EGR-1) gene product is a transcription factor with role in differentiation and growth. We have previously shown that expression of exogenous EGR-1 in various human tumor cells unexpectedly and markedly reduces growth and tumorigenicity and, conversely, that suppression of endogenous Egr-1 expression by antisense RNA eliminates protein expression, enhances growth, and promotes...

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Identifiers

PMID: 8876223
DOI: 10.1073/pnas.93.21.11831
PMCID: PMC38144

Genes

NAB1
NAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.PMID 8876223Read ↗

The Early-Immediate Gene EGR-1 Is Induced by Transforming Growth Factor-β and Mediates Stimulation of Collagen Gene ExpressionSemantic proximity Read ↗

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis.Semantic proximity Read ↗

The transcription factor EGR-1 directly transactivates the fibronectin gene and enhances attachment of human glioblastoma cell line U251.Semantic proximity Read ↗

Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2.Semantic proximity Read ↗

Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo.Semantic proximity Read ↗

Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formationSemantic proximity Read ↗

Early growth response 1 (EGR1): A gene with as many names as biological functionsSemantic proximity Read ↗

Suppression of v-sis-dependent transformation by the transcription factor, Egr-1.Semantic proximity Read ↗

EGR-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells.Semantic proximity Read ↗

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RRIG1 Mediates Effects of Retinoic Acid Receptor β2 on Tumor Cell Growth and Gene Expression through Binding to and Inhibition of RhoASemantic proximity Read ↗

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