Article
Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1996
Liu C, Adamson E, Mercola D
Abstract excerpt
The early growth response 1 (EGR-1) gene product is a transcription factor with role in differentiation and growth. We have previously shown that expression of exogenous EGR-1 in various human tumor cells unexpectedly and markedly reduces growth and tumorigenicity and, conversely, that suppressio...
Topics
- Binding Sites
- Cell Differentiation
- Cell Division
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Fibrosarcoma
- Genes, Reporter
- Genetic Vectors
- Humans
- Immediate-Early Proteins
- Kinetics
- Phenotype