Article
In vitro activation of distinct molecular and cellular phenotypes after induction of differentiation in a human neuroblastoma cell line.
Cancer research - 15 Aug 1992
Gaetano C, Matsumoto K, Thiele C J
Abstract excerpt
In this report we provide evidence for the activation of distinct differentiation pathways during treatment of the neuroblastoma cell line SMS-KCNR with 1 mM dibutyryl cyclic AMP (dbcAMP) and/or 5 microM retinoic acid (RA). Our results show that the adrenal gland specific gene pG2 is induced only...
Topics
- Bucladesine
- Cell Differentiation
- G1 Phase
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Genetic Markers
- Humans
- Neuroblastoma
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- S Phase
- Time Factors
- Transcription, Genetic
- Tretinoin
- Tumor Cells, Cultured
- Vasoactive Intestinal Peptide