Identification of a Discrete Promoter Region of the Human GnRH Gene That Is Sufficient for Directing Neuron-Specific Expression: A Role for POU Homeodomain Transcription Factors

Abstract excerpt

The human GnRH (hGnRH) gene is expressed, and the GnRH decapeptide produced, primarily in the GnRH neurons of the diencephalon. The molecular elements important for the cell-specific expression and regulation of the hGnRH gene are not well established at this time; therefore, we have used a transgenic mouse model to isolate cis-regulatory elements important for directing gene expression to GnRH neurons in the...