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Article

The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.

The EMBO journal - 15 Dec 2003

Inoue Haruhisa, Tsukita Kayoko, Iwasato Takuji, Suzuki Yasuyuki, Tomioka Masanori, Tateno Minako, Nagao Masahiro, Kawata Akihiro, Saido Takaomi C, Miura Masayuki, Misawa Hidemi, Itohara Shigeyoshi, Takahashi Ryosuke

Abstract excerpt

Mutant copper/zinc superoxide dismutase (SOD1)-overexpressing transgenic mice, a mouse model for familial amyotrophic lateral sclerosis (ALS), provides an excellent resource for developing novel therapies for ALS. Several observations suggest that mitochondria-dependent apoptotic signaling, including caspase-9 activation, may play an important role in mutant SOD1-related neurodegeneration. To elucidate the role...

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Source

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Identifiers

PMID: 14657037
DOI: 10.1093/emboj/cdg634
PMCID: PMC291829

Genes

SOD1
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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