Article
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
Brain research - 31 May 2005
Holasek Silvina S, Wengenack Thomas M, Kandimalla Karunya K, Montano Carolina, Gregor Dawn M, Curran Geoffry L, Poduslo Joseph F
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by the degeneration of upper and lower motor neurons (MNs). Central nervous system features include a loss of Betz cells and other pyramidal cells from sensorimotor cortex. The intrinsic mechanism underlying this selective motor neuron loss has not been identified. A recent in vitro study has provided evidence of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.