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Article

Systemic administration of scAAV9-IGF1 extends survival in SOD1G93A ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway.

Brain research bulletin - 1 May 2018

Wang Wan, Wen Di, Duan Weisong, Yin Juntao, Cui Can, Wang Ying, Li Zhongyao, Liu Yakun, Li Chunyan

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is closely associated with a reduction of neurotrophic factors in the central nervous system (CNS). Insulin-like growth factor 1 (IGF1)-encoding vectors delivered via intramuscular and intraparenchymal spinal cord injections have conferred therapeutic benefits in ALS model mice, although the development of a noninvasive delivery route is still needed. Intravenous administration...

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Identifiers

PMID: 29499331
DOI: 10.1016/j.brainresbull.2018.02.015

Genes

IGF1
SOD1
TNF

Variants

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