Article
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Experimental neurology - 1 May 2007
Kiaei Mahmoud, Kipiani Khatuna, Calingasan Noel Y, Wille Elizabeth, Chen Junyu, Heissig Beate, Rafii Shahin, Lorenzl Stefan, Beal M Flint
Abstract excerpt
Whether increased levels of matrix metalloproteinases (MMPs) correspond to a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) needs to be determined and it is actively being pursued. Here we present evidence suggesting that MMP-9 contributes to the motor neuron cell death in ALS. We examined the role of MMP-9 in a mouse model of familial ALS and found that lack of MMP-9 increased survival (31%) in...
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