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Article

Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.

Neurobiology of disease - 1 Mar 2008

Wang Lijun, Sharma Kamal, Deng Han-Xiang, Siddique Teepu, Grisotti Gabriella, Liu Erdong, Roos Raymond P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons (MNs). Approximately 10% of ALS cases are familial (known as FALS), and approximately 20% of FALS cases are caused by mutations in Cu/Zn superoxide dismutase type 1 (SOD1). Mutant (MT) SOD1 induces FALS as a result of a toxicity that remains poorly defined. Several studies suggest that the...

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Source

Identifiers

PMID: 18054242
DOI: 10.1016/j.nbd.2007.10.004

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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