Article
Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 2003
Kostka Heike, Schwarz Thomas, Schellong Sebastian, Mix Cornelia, Kuhlisch Eberhard, Temelkova-Kurktschiev Theodora, Henkel Elena, Köhler Carsta, Gehrisch Siegmund, Siegert Gabriele
Abstract excerpt
Factor V Leiden is a well-known risk factor for venous thrombosis. The dual role of factor V as a coagulatory and anticoagulatory cofactor permits the assumption that further mutations in the factor V gene are of importance in the study of the risk of thrombosis. Relevant studies to date have given rise to a controversy over this risk for the HR2 haplotype. For the G allele, defined in our work group as a G at...
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