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Article

Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 2007

Martinelli Nicola, Girelli Domenico, Ferraresi Paolo, Olivieri Oliviero, Lunghi Barbara, Manzato Franco, Corrocher Roberto, Bernardi Francesco

Abstract excerpt

A common factor V gene haplotype, the FVR2 haplotype (FVHR2), has been associated with a reduced cofactor activity in activated protein C-mediated activated factor VIII inactivation. Our aim was to investigate the role of FVHR2 as a possible determinant of factor VIII levels in a population study. A total of 516 individuals (401 men, 115 women; mean age 58.4 +/- 10.8 years) were enrolled within the frame of a...

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Identifiers

PMID: 17287628
DOI: 10.1097/MBC.0b013e328011c06d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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