Article
A FV multiallelic marker detects genetic components of APC resistance contributing to venous thromboembolism in FV Leiden carriers.
Thrombosis and haemostasis - 1 Jun 2003
Mingozzi Federico, Legnani Cristina, Lunghi Barbara, Scanavini Daniela, Castoldi Elisabetta, Palareti Gualtiero, Marchetti Giovanna, Bernardi Francesco
Abstract excerpt
Activated protein C resistance (APCR) is a major risk factor for venous thromboembolism (VTE). Although the factor V (FV) Leiden mutation accounts for the vast majority of APCR cases, other polymorphisms may contribute to the APCR phenotype. Genetic components of APCR and thrombophilia were investigated by two dinucleotide repeats, characterized in introns 2 and 11 of the FV gene. Only the intron 11 marker was...
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