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Article

A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype.

Blood - 15 Aug 1997

Bernardi F, Faioni E M, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci P M

Abstract excerpt

Factor V gene polymorphisms were investigated to detect components that may contribute to the activated protein C (APC) resistance phenotype in patients with venous thromboembolism. A specific factor V gene haplotype (HR2) was defined by six polymorphisms and its frequency was found to be similar in normal subjects coming from Italy (0.08), India (0.1), and Somalia (0.08), indicating that it was originated by...

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PMID: 9269773

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype.PMID 9269773Read ↗

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Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance due to a common factor V gene mutation is a major risk factor for venous thrombosis.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Prevalence of activated protein C resistance and analysis of clinical profile in thromboembolic patients. A Belgian prospective study.Semantic proximity Read ↗

Early days of APC resistance and FV Leiden.Semantic proximity Read ↗

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.Semantic proximity Read ↗

Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance: from phenotype to genotype and clinical practice.Semantic proximity Read ↗

The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.Semantic proximity Read ↗

Investigation of genotype-dependent differences in factor V activity as well as response to activated protein C by application of different methods.Semantic proximity Read ↗

A Retrospective Cross-sectional Study on Activated Protein C Resistance (Factor V Leiden): an Independent, Gender-dependent Risk Factor for Venous ThromboembolismSemantic proximity Read ↗

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