Article

Detection of New Polymorphic Markers in the Factor V Gene: Association with Factor V Levels in Plasma

1996-01-01

Abstract excerpt

Summary Three novel polymorphisms were found in the repeated region of the large exon 13 of factor V gene, one giving rise to a codon dimorphism (Serl240) and two causing aminoacid substitutions (Hisl299Arg, Leul257Ile). An increasing frequency of the Argl299 (R2 allele) correlated with a decreasing mean plasma factor V activity in the groups of subjects under study, which included 26 unrelated subjects with parti...

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Literature Corpus work: ad3cbd4f-9e80-5e43-b913-7ccbd176e666
DOI: 10.1055/s-0038-1650219

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