Article
The infrequent simultaneous genetic alterations in glioblastoma multiforme (LOH 10, 17, 19q, TP53 mutation and EGFR amplification) with short clinical course.
Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2007
Jesionek-Kupnicka D, Kulczycka D, Rieske P, Szybka M, Jabłońska J, Potemski P, Kolasa P, Liberski P P, Kordek R
Abstract excerpt
We described the case of an unusual, complex genetic alteration in 57 year-old male patient with glioblastoma multiforme (GBM) with short survival (6 and half months). Alterations consisted of p53 mutation, LOH 10, LOH 17, LOH 19q and EGFR amplification. LOH1p, LOH 9 and LOH 13 were negative. Immunohistochemical study did not correlate with molecular results. The overexpression of TP53 protein and RB protein was...
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