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Article

Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site.

Cancer research - 15 Feb 1995

Reifenberger G, Reifenberger J, Ichimura K, Collins V P

Abstract excerpt

We have recently reported that a subset of human malignant gliomas shows amplification and overexpression of multiple genes from chromosomal segment 12q13-14, including CDK4, SAS, and MDM2. In the present study we have performed an allelotyping for 16 polymorphic loci spanning both arms of chromo...

Topics

Alleles
Astrocytoma
Chromosomes, Human, Pair 12
Gene Amplification
Gene Deletion
Glioblastoma
Glioma
Heterozygote
Humans

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7850781

Genes

CDK4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7850781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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