Article
No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract.
Oncology reports - 1 Jan 2004
Stoehr Robert, Brinkmann Anke, Filbeck Thomas, Gamper Christoph, Wild Peter, Blaszyk Hagen, Hofstaedter Ferdinand, Knuechel Ruth, Hartmann Arndt
Abstract excerpt
Mutational activation of the MAP kinase pathway is frequently found in various cancers. Recently, activating mutations in the B-RAF gene, an important activator of this pathway, have been described in several tumor types including melanoma, colorectal and papillary thyroid cancer. The most frequent mutation in exon 15 (V599E), as well as several other mutations within exons 11 and 15 result in constitutive...
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