Article
Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair.
Molecular cell - 1 Jul 1998
Chen C, Umezu K, Kolodner R D
Abstract excerpt
Three temperature-sensitive S. cerevisiae RFA1 alleles were found to cause elevated mutation rates. These mutator phenotypes resulted from the accumulation of base substitutions, frameshifts, gross deletions (8 bp-18 kb), and nonreciprocal translocations. A representative rfa1 mutation exhibited...
Topics
- Alleles
- Base Sequence
- Chromosome Aberrations
- Chromosome Deletion
- Chromosomes, Fungal
- DNA
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Endonucleases
- Frameshift Mutation
- Fungal Proteins
- Humans
- Loss of Heterozygosity
- Models, Genetic
- Molecular Sequence Data