Article
Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 2000
Erdeniz N, Rothstein R
Abstract excerpt
In Saccharomyces cerevisiae, RAD1 and RAD52 are required for alternate pathways of mitotic recombination. Double-mutant strains exhibit a synergistic interaction that decreases direct repeat recombination rates dramatically. A mutation in RFA1, the largest subunit of a single-stranded DNA-binding protein complex (RP-A), suppresses the recombination deficiency of rad1 rad52 strains (J. Smith and R. Rothstein, Mol....
Topics
- Alleles
- Amino Acid Sequence
- DNA Repair Enzymes
- DNA, Fungal
- DNA, Single-Stranded
- DNA-Binding Proteins
- Endonucleases
- Endosomal Sorting Complexes Required for Transport
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Molecular Sequence Data
- Mutation
- Rad52 DNA Repair and Recombination Protein