Article
Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.
Genetics - 1 Jun 2002
Soustelle Christine, Vedel Michèle, Kolodner Richard, Nicolas Alain
Abstract excerpt
In Saccharomyces cerevisiae, meiotic recombination is initiated by transient DNA double-stranded breaks (DSBs). These DSBs undergo a 5' --> 3' resection to produce 3' single-stranded DNA ends that serve to channel DSBs into the RAD52 recombinational repair pathway. In vitro studies strongly suggest that several proteins of this pathway--Rad51, Rad52, Rad54, Rad55, Rad57, and replication protein A (RPA)--play a...
Topics
- Crossing Over, Genetic
- DNA-Binding Proteins
- Gene Conversion
- Meiosis
- Mutation
- Recombination, Genetic
- Replication Protein A
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Spores, Fungal