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Article

Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance.

Biochimie - 1 Jan 2000

Smith J, Zou H, Rothstein R

Abstract excerpt

Replication protein A (RPA) is a heterotrimeric single-stranded DNA binding protein whose role in DNA replication, recombination and repair has been mainly elucidated through in vitro biochemical studies utilizing the mammalian complex. However, the identification of homologs of all three subunits in Saccharomyces cerevisiae offers the opportunity of examining the in vivo role of RPA. In our laboratory, we have...

Topics

DNA Polymerase I
DNA Primase
DNA Repair
DNA Replication
DNA-Binding Proteins
Genes, Lethal
Mutation
Phenotype
Replication Protein A
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere

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Identifiers

PMID: 10717390
DOI: 10.1016/s0300-9084(00)00183-8

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