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Article

Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer.

Cancer letters - 20 Feb 2003

Smith Tasha R, Miller Mark Steven, Lohman Kurt, Lange Ethan M, Case L Douglas, Mohrenweiser Harvey W, Hu Jennifer J

Abstract excerpt

Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12565173
DOI: 10.1016/s0304-3835(02)00595-5

Genes

XRCC1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer.PMID 12565173Read ↗

DNA-repair genetic polymorphisms and breast cancer risk.Semantic proximity Read ↗

XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.Semantic proximity Read ↗

Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer.Semantic proximity Read ↗

XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis.Semantic proximity Read ↗

Association between XRCC3 Thr241Met Polymorphism and Risk of Breast Cancer: Meta-Analysis of 23 Case-Control Studies.Semantic proximity Read ↗

XRCC1 gene polymorphisms and breast cancer risk in different populations: a meta-analysis.Semantic proximity Read ↗

Association of DNA repair genes XRCC1 (Arg399Gln), (Arg194Trp) and XRCC3 (Thr241Met) polymorphisms with the risk of breast cancer: a case-control study in Egypt.Semantic proximity Read ↗

Association between the XRCC3 Thr241Met polymorphism and breast cancer risk: an updated meta-analysis of 36 case-control studies.Semantic proximity Read ↗

Impact of XRCC1 genetic variants on its tissue expression and breast cancer risk: A case-control study.Semantic proximity Read ↗

Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case-control studies.Semantic proximity Read ↗

DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies.Semantic proximity Read ↗

No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study.Semantic proximity Read ↗

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