Article
XRCC1 gene polymorphisms and breast cancer risk in different populations: a meta-analysis.
Breast (Edinburgh, Scotland) - 1 Jun 2009
Li Huihua, Ha Tam Cam, Tai Bee Choo
Abstract excerpt
We performed a meta-analysis to investigate the role of XRCC1 polymorphisms Arg194Trp, Arg280His and Arg399Gln in breast cancer. The results were pooled in a manner that appropriately reflects a biological model of gene effect using a random effects logistic regression model without multiple comparisons. Forty studies from 31 reports were included with 10 465 cases and 10 888 controls at Arg194Trp, 6156 cases and...
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