Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2014

Zhou Yingying, Zhou Weibing, Liu Qiong, Fan Zhiru, Yang Zhen, Tu Qingsong, Li Li, Liu Haifeng

Abstract excerpt

Radiotherapy is an important weapon in the treatment of breast cancer, but normal tissue injury after radiotherapy can be a threat for patients. Genetic markers conferring the ability to identify hyper-sensitive patients at risk of normal tissue injury in advance would considerably improve therapy. Association studies on genetic variation and occurrence of normal tissue injury can help us identify such markers,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to XRCC1 gene

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Radiation Injuries

Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 24292986
DOI: 10.1007/s13277-013-0990-x

Genes

XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients.PMID 24292986Read ↗

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis.Semantic proximity Read ↗

Impact of XRCC1 genetic variants on its tissue expression and breast cancer risk: A case-control study.Semantic proximity Read ↗

Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach.Semantic proximity Read ↗

XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls.Semantic proximity Read ↗

Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.Semantic proximity Read ↗

Predictive value of Xrcc1 gene polymorphisms for side effects in patients undergoing whole breast radiotherapy: a meta-analysis.Semantic proximity Read ↗

Genetic variation in normal tissue toxicity induced by ionizing radiation.Semantic proximity Read ↗

Assessment of the Link between XRCC1 Arg399Gln Polymorphism and Breast Cancer: a Meta-Analysis in a Single Ethnic Group.Semantic proximity Read ↗

Association of DNA repair genes XRCC1 (Arg399Gln), (Arg194Trp) and XRCC3 (Thr241Met) polymorphisms with the risk of breast cancer: a case-control study in Egypt.Semantic proximity Read ↗

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancerSemantic proximity Read ↗

DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients.Semantic proximity Read ↗

DNA Repair Mechanism Gene, XRCC1A ( Arg194Trp) but not XRCC3 ( Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case-Control Study in Northeastern Region of India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.