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Article

XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2014

Zhou Yingying, Zhou Weibing, Liu Qiong, Fan Zhiru, Yang Zhen, Tu Qingsong, Li Li, Liu Haifeng

Abstract excerpt

Radiotherapy is an important weapon in the treatment of breast cancer, but normal tissue injury after radiotherapy can be a threat for patients. Genetic markers conferring the ability to identify hyper-sensitive patients at risk of normal tissue injury in advance would considerably improve therap...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 24292986
DOI: 10.1007/s13277-013-0990-x

Genes

XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24292986-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients.PMID 24292986Read ↗

Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis.Semantic proximity Read ↗

Impact of XRCC1 genetic variants on its tissue expression and breast cancer risk: A case-control study.Semantic proximity Read ↗

Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach.Semantic proximity Read ↗

XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls.Semantic proximity Read ↗

Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.Semantic proximity Read ↗

Predictive value of Xrcc1 gene polymorphisms for side effects in patients undergoing whole breast radiotherapy: a meta-analysis.Semantic proximity Read ↗

Genetic variation in normal tissue toxicity induced by ionizing radiation.Semantic proximity Read ↗

Assessment of the Link between XRCC1 Arg399Gln Polymorphism and Breast Cancer: a Meta-Analysis in a Single Ethnic Group.Semantic proximity Read ↗

Association of DNA repair genes XRCC1 (Arg399Gln), (Arg194Trp) and XRCC3 (Thr241Met) polymorphisms with the risk of breast cancer: a case-control study in Egypt.Semantic proximity Read ↗

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancerSemantic proximity Read ↗

DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients.Semantic proximity Read ↗

DNA Repair Mechanism Gene, XRCC1A ( Arg194Trp) but not XRCC3 ( Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case-Control Study in Northeastern Region of India.Semantic proximity Read ↗

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