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Article

The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and Behavior

15 Aug 2007

Abstract excerpt

GPR54 is a G-protein-coupled receptor, which binds kisspeptins and is widely expressed throughout the brain. Kisspeptin-GPR54 signaling has been implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (GnRH) secretion, and mutations or deletions of GPR54 cause hypogonadotropic hypogonadism in humans and mice. Other reproductive roles for kisspeptin-GPR54 signaling, including the...

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PMID: 17699664
DOI: 10.1523/jneurosci.2099-07.2007

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The Kisspeptin Receptor GPR54 Is Required for Sexual Differentiation of the Brain and BehaviorPMID 17699664Read ↗

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Disrupted Kisspeptin Signaling in GnRH Neurons Leads to Hypogonadotrophic HypogonadismSemantic proximity Read ↗

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Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice.Semantic proximity Read ↗

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system.Semantic proximity Read ↗

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Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones.Semantic proximity Read ↗

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.Semantic proximity Read ↗

New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1Semantic proximity Read ↗

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