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Article

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.

Human molecular genetics - 15 Jan 2004

Mohindra Atul, Bolderson Emma, Stone Jason, Wells Michael, Helleday Thomas, Meuth Mark

Abstract excerpt

Homologous recombination repair (HRR) is required for both the repair of DNA double strand breaks (DSBs) and the maintenance of the integrity of DNA replication forks. To determine the effect of a mutant allele of the RAD51 paralog XRCC2 (342delT) found in an HRR-defective tumour cell line, 342de...

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Source

Identifiers

PMID: 14645207
DOI: 10.1093/hmg/ddh022

Genes

XRCC2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14645207-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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